Caspase-cleaved cytokeratin-18 and tumour regression in gastro-oesophageal adenocarcinomas treated with neoadjuvant chemotherapy

Table 3 Univariate and multivariate analyses showing predictive factors for disease-specific and overall survival in neoadjuvant and surgery only groups

	Univariate analysis		Multivariate analysis
	DSS	OS	OS
Neoadjuvant group
Caspase-cleaved CK-18 positivity	0.975	0.865	1.32
TRG 1-3 vs 4-5	0.038	0.136	0.109
Tumour diff. (well/mod vs poor)	0.087	0.101	0.32
T stage (T1, 2 and 3, 4)	0.07	0.09	0.101
N stage (N0 and > N1)	0.106	0.124	0.23
M stage (M0 and > M0)	0.23	0.14	1.72
Vascular invasion	0.87	0.76	0.86
Perineural invasion	1.32	1.455	1.76
Resection margin involvement	2.34	1.98	0.24
Surgery only group
Caspase-cleaved CK-18 positivity	0.003	0.668	0.10
TRG 1-3 vs 4-5	0.87	0.003	0.23
Tumour diff. (well/mod vs poor)	0.39	0.34	0.21
T stage (T1, 2 and 3, 4)	0.04	0.08	0.19
N stage (N0 and > N1)	0.16	0.10	0.43
M stage (M0 and > M0)	1.27	1.64	1.99
Vascular invasion	1.98	1.67	1.34
Perineural invasion	1.56	1.99	2.43
Resection margin involvement	0.34	0.25	0.34

DSS: Disease-specific survival; OS: Overall survival; CK-18: Cytokeratin-18; TRG: Tumour regression grade; diff.: Differentiation.