Over-expression of uPA increases risk of liver injury in pAAV-HBV transfected mice

Table 1 Statistical analysis of the liver pathogenic rates for mice in different groups (%)

Group	1	2	3
NP	8 (100)	8 (80)	2 (13.3)
P1	0	2 (20)	2 (13.3)
P2	0	0	5 (33.3)
P3	0	0	6 (40)
Total	8	10	15

Group 1: Adeno-associated virus (AAV)-internal ribosome entry site transfected doxycycline (Dox)-induced in-alb-urokinase plasminogen activator (uPA) mice; Group 2: AAV-hepatitis B virus (HBV) transfected non-induced in-alb-uPA mice; Group 3: AAV-HBV transfected Dox-induced in-alb-uPA mice. NP stands for number of the non-pathogenic mice; P1 stands for number of mice in which the liver pathogenic area is below 10%; P2 stands for number of mice in which the liver pathogenic area ranges between 10% and 30%; P3 stands for number of mice in which the liver pathogenic area is above 30%.