Risk of fracture in celiac disease: Gender, dietary compliance, or both?

Table 1 Demography, clinical information and data on fractures in the peripheral skeleton of celiac disease patients and disease controls (Functional gastrointestinal disorders) at the time of the study

	CD patients	Control population	P value
No. of patients (F/M)	265 (223/42)	530 (446/84)
Median age (yr) (range)	42 (18-85)	43 (16-87)
Age at diagnosis (yr) median (range)	30 (1-80)	-
BMI (kg/m2, mean ± SE)	22.5 ± 0.2	24.3 ± 0.2	0.001
Age at menarche (yr) median (range)	13 (9-17)	12 (9-20)
Age at menopause (yr) median (range)	48 (30-54)	49 (36-59)
Person-years before diagnosis	7028	14 532
Person-years after diagnosis	2815	5628
Total No. of fractures	89	93	0.0001
Total No. of cases with at least one fracture	61	82	0.02
No. of patients with at least one fracture before diagnosis	40	45	0.006
No. of patients with at least one fracture after diagnosis	21	37
Age at first fracture before diagnosis (yr), median (range)	10 (2-61)	15 (1-74)
Age at first fracture after diagnosis (yr), median (range)	21 (5-75)	37 (6-71)
Type of trauma producing fracture (No. of cases)
Mild	27	24
Moderate	24	34
Severe/sports	10	24

CD: Celiac disease; BMI: Body mass index.