Molecular cross-talk between Helicobacter pylori and human gastric mucosa

Figure 1 Helicobacter pylori penetration in human gastric epithelium in vivo. Three Helicobacter pylori (H. pylori) organisms (enlarged in a; 16 800 ×) lying in the deep intercellular intraepithelial space, just above the basal membrane. Note also luminal bacteria (top) overlying an apparently preserved tight junction, dilation of the underlying intercellular space, filled with lateral membrane plications, and an intraepithelial granulocyte (middle right, 6300 ×). Reprinted from Necchi et al[57], with permission from Elsevier.