Bio-mathematical models of viral dynamics to tailor antiviral therapy in chronic viral hepatitis

Table 1 Free virion and infected cell half lives computed by different models of HBV dynamics

Author	Therapy	HBeAg	Virion T1/2 (h)	Inf. cell T1/2 (d)	Antiviral effectiveness (%)
Nowak et al[13]	LMV 20-600 mg	POS	24	10-100	87-99
Lewin et al[16]	LMV 150 mg	POS	28.5	2.4 > 120	95
	LMV + FCV				99
Tsiang et al[14]	ADV	POS	26.4	11-30	99
Wolters et al[18]	LMV150 mg	POS	131	< 0-331	92-96
Wolters et al[18]	ETV	POS/neg	161	5.2-31.8	87-98
Sypsa et al[19]	PegIFN2b 1-200 mg	neg	12.71	2.7-75	83
	LMV 100 mg				96
Colombatto et al[20]	PegIFN2a 180 mg	neg	nc	2.5-77.3	88
	PegIFN2a + LMV		8.21	4.7-33.3	99.6 (87)
	LMV 100 mg		9.51	4.3-56.5	99.4 (88)

¹Tighter sampling schedule during the first 48 h.