Spontaneous necrosis of solid gallbladder adenocarcinoma accompanied with pancreaticobiliary maljunction

Figure 4 Low magnification view of the elevated lesion of the fundus showing obvious nodule necrosis. (A, HE, loupe) including non-viable adenocarcinoma cells and remnants of glandular structures and vessel fragments (B, black arrow) (HE, × 40), viable cancer cell nests invading perimuscular connective tissue but not penetrating the serosa in the muscularis propria and subcutaneous layer beneath the necrotic nodule (C, black arrow) (HE, × 20), and a solid adenocarcinoma (D, black arrow) (HE, × 100).