Role of iron in hepatic fibrosis: One piece in the puzzle

Figure 1 The involvement of iron in oxidative stress and its cytotoxic conse-quences. Iron catalyses the production of the reactive molecules OH^• (via the Fenton reaction) and NO₂⁺, which promote lipid peroxidation and protein damage leading to cellular injury. NOS, nitric oxide synthase; ^•NO, nitric oxide; ONOO^-, peroxynitrite; O2^•-, superoxide radical; OH^•, hydroxyl radical; H₂O₂, hydrogen peroxide; NO₂⁺, nitronium anion; Fe, iron; NAFLD, non-alcoholic fatty liver disease.