Metabolic liver disease of obesity and role of adipose tissue in the pathogenesis of nonalcoholic fatty liver disease

Table 1 Histological scoring and staging system for NASH

	Steatosis Macrovesicular	Steatohepatitis		Stages of NASH Fibrosis
		Lobular Inflammation	Ballooning
Definition and score	Large fat droplet with signet cell appearance of hepatocytes	Assessment of inflammatory foci on 200 × field	Swollen hepatocytes	On trichome staining
0	Less than 5%	Less than 2 foci	None	None
1	5% to 33%	2 to 4 foci	Few	Perisinusoidal (zone 3) or periportal 1a-mild, zone 3 1b-moderate, zone 3 1c-portal or periportal
2	33% to 66%	More than 4 foci	Many cells or prominent ballooning	Perisinusoidal (zone 3) and portal/periportal
3	More than 66%	-	-	Bridging
4	-	-	-	Cirrhosis