Upper gastrointestinal function and glycemic control in diabetes mellitus

Figure 3 Effect of initially more rapid intraduodenal glucose infusion (3 kcal/min between t = 0 and 15 min and 0. 71 kcal/min between t = 15 and 120 min) (closed symbols) compared to constant infusion (1 kcal/min between t = 0 and 120 min) (open symbols) in healthy subjects (triangles) and patients with type 2 diabetes (circles) on (A) blood glucose, (B) plasma insulin, (C) plasma GLP-1, and (D) plasma GIP. Each pair of curves differs between 0 and 30 min for variable vs constant intraduodenal infusion (P < 0.05). Adapted from O’Donovan et al 2004[52].