Mutations in surface and polymerase gene of chronic hepatitis B patients with coexisting HBsAg and anti-HBs

Table 1 Clinical data of two groups of patients

	Groups
Clinical factors	Positive anti-HBs	Negative anti-HBs	P
Age in years	40.3 ± 13.2	42.5 ± 14.7	0.7672
Sex, M/F	5/6	7/5	0.6531
Patients with HbsAg, n (%)	11 (100)	12 (100)
Patients with HbeAg, n (%)	9 (81.8)	11 (91.7)
Patients with anti-HBe, n (%)	1 (9.1)	0 (0)
ALT in IU/L	65.9 ± 30.5	98.9 ± 42.0	0.6541
HBV-DNA (log)	7.0 ± 1.60	6.87 ± 0.9	0.5263
Number of amino acid residues mutations in S gene, n (%)	34/41 (82.9)	7/41 (17.1)

Fisher’s exact test was used for the categorized data; two-tailed Student’s t test was used for ALT levels, age and HBV DNA levels (log, copies mL^-1).