Animal experiment and clinical study of effect of gamma-interferon on hepatic fibrosis

Figure 1 Histological section of rat liver after 12-weeks of CCl₄ treatment under polarizes after staining with Sirius Red. Red and yellow represented collagen type I and green collagen type III (the same below). The pattern of micronodular cirrhosis is evident. × 100

Figure 2 Histological section of rat liver after 8-weeks of treatment with high-dose IFN-γ and 12 weeks of CCl₄ under polarizes after staining with Sirius Red. × 100

Figure 3 Histological section of rat liver after 8-weeks of treatment with medium-dose IFN-γ and 12 weeks of CCl₄ under polarizes after staining with Sirius Red. × 100

Figure 4 Histological section of rat liver after 8-weeks of treatment with low-dose IFN-γ and 12 weeks of CCl₄ under polarizes after staining with Sirius Red. × 100

Figure 5 Histological section of rat liver after 8-weeks of treatment with colchicine and 12 weeks of CCl₄ under polarizes after staining with Sirius Red. × 100

Figure 6 Histological section of liver biopsy of a patient with chronic hepatitis B before IFN-γ treatment under polarizes after staining with Sirius Red. Figure 6 show two different fields. × 100