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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 14, 2023; 29(34): 5075-5081
Published online Sep 14, 2023. doi: 10.3748/wjg.v29.i34.5075
Published online Sep 14, 2023. doi: 10.3748/wjg.v29.i34.5075
Role of biochemical markers and autoantibodies in diagnosis of early-stage primary biliary cholangitis
Yu-Jin Zhu, Jing Li, Graduate School, Tianjin Medical University, Tianjin 300041, China
Yong-Gang Liu, Department of Pathology, Clinical School of the Second People's Hospital, Tianjin 300110, China
Yong Jiang, Department of Gastroenterology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China
Xiao-Jing Cheng, Xu Han, Chun-Yan Wang, Jia Li, Department of Gastroenterology, Clinical School of the Second People's Hospital, Tianjin 300110, China
Author contributions: Zhu YJ wrote the manuscript; Zhu YJ, Cheng XJ, and Han X contributed to data collation; Zhu YJ and Li J contributed to statistical analysis; Liu YG contributed to liver pathology reading; Jiang Y, Wang CY, and Li J contributed to manuscript revision; Wang CY and Li J contributed to research supervision; Wang CY contributed to project design.
Institutional review board statement: The study protocol conforms to the ethical guidelines of the 1975 Declaration of Helsinki and was approved by the local Ethics Committee (Clinical School of the Second People's Hospital of Tianjin).
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All authors have no conflict of interest to disclose.
Data sharing statement: The data underlying this article can be available in this article and in its online supplementary material or from the first author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chun-Yan Wang, Doctor, Chief Doctor, Department of Gastroenterology, Clinical School of the Second People's Hospital, No. 7 Sudi South Road, Nankai District, Tianjin 300110, China. wangchunyan123@tmu.edu.cn
Received: June 4, 2023
Peer-review started: June 4, 2023
First decision: June 21, 2023
Revised: July 15, 2023
Accepted: August 25, 2023
Article in press: August 25, 2023
Published online: September 14, 2023
Peer-review started: June 4, 2023
First decision: June 21, 2023
Revised: July 15, 2023
Accepted: August 25, 2023
Article in press: August 25, 2023
Published online: September 14, 2023
Core Tip
Core Tip: This is a retrospective study of the characteristics of early-stage primary biliary cholangitis (PBC) patients, in which we found the suggestive role of γ-glutamyl transferase as an indicator of cholestasis in the early diagnosis of PBC. We also found that when anti-mitochondria antibody (AMA) and AMA-M2 were negative, positivity for anti-nuclear antibody (ANA) especially ANA centromere indicates early-stage PBC.