Basic Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 7, 2023; 29(29): 4557-4570
Published online Aug 7, 2023. doi: 10.3748/wjg.v29.i29.4557
Effect of exogenous hydrogen sulfide in the nucleus tractus solitarius on gastric motility in rats
Hong-Zhao Sun, Chen-Yu Li, Yuan Shi, Jin-Jin Li, Yi-Ya Wang, Li-Na Han, Lu-Jie Zhu, Ya-Fei Zhang
Hong-Zhao Sun, Chen-Yu Li, Yuan Shi, Jin-Jin Li, Yi-Ya Wang, Li-Na Han, Lu-Jie Zhu, Ya-Fei Zhang, College of Life Science, Qi Lu Normal University, Zhangqiu 250200, Shandong Province, China
Author contributions: Sun HZ and Li CY contributed equally to this work; Sun HZ conceived and designed the experiments; Li CY, Shi Y, Li JJ, Wang YY, Han LN, Zhu LJ, and Zhang YF performed the experiments; Sun HZ and Li CY analyzed the data; Sun HZ provided reagents/materials/analysis tools; Li CY authored the paper; all authors have read and approved the final manuscript.
Supported by the Natural Science Foundation of Shandong Province, No. ZR2019MC020.
Institutional animal care and use committee statement: All animal procedures were reviewed and approved by the Institutional Animal Care and Use Committee (IACUC) of Qi Lu Normal University (Approval No. 14276).
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong-Zhao Sun, PhD, Professor, College of Life Science, Qi Lu Normal University, No. 2 Wenbo Road, Zhangqiu 250200, Shandong Province, China. sunhongzhao18@126.com
Received: May 18, 2023
Peer-review started: May 18, 2023
First decision: June 20, 2023
Revised: June 29, 2023
Accepted: July 19, 2023
Article in press: July 19, 2023
Published online: August 7, 2023
Core Tip

Core Tip: This study revealed a significant inhibitory effect of exogenous hydrogen sulfide on gastric motility in rats. This effect appeared to involve the release of substance P, potentially activating the transient receptor potential vanilloid 1 pathway mediated by nuclear factor kappa-B channels.