Basic Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 14, 2023; 29(18): 2818-2835
Published online May 14, 2023. doi: 10.3748/wjg.v29.i18.2818
BanXiaXieXin decoction treating gastritis mice with drug-resistant Helicobacter pylori and its mechanism
Xiao-Hua Li, Jia-Yin Xu, Xue Wang, Li-Juan Liao, Liang Huang, Yan-Qiang Huang, Zeng-Feng Zhang
Xiao-Hua Li, Duate School, Guangxi Medical University, Nanning 5330021, Guangxi Zhuang Autonomous Region, China
Jia-Yin Xu, Xue Wang, Li-Juan Liao, Yan-Qiang Huang, Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance, Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China
Liang Huang, Key Laboratory of the Prevention and Treatment of Drug Resistant Microbial Infecting, Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China
Zeng-Feng Zhang, Department of Microbiology, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Author contributions: Li XH and Xu JY consulted literature, performed experiments, collected and analyzed data and wrote the first draft, making equal contributions to this work; Wang X and Liao LJ corrected it; Huang L, Huang YQ, and Zhang ZF designed, checked, modified, and completed the manuscript, making equal contributions to this work as co-corresponding authors, Huang L (youyihuangl@163.com) is the first corresponding author; all authors approved the final version of the article.
Supported by the National Natural Science Foundation of China, No. 81760739; Special Fund Projects for Guide Local Science and Technology Development by the China government, No. GUIKEZY20198004; and 2022 Guangxi Graduate Education Innovation Plan Project, No. YCBZ2022071.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Youjiang Medical University for Nationalities Institutional Review Board (approval No. 20220110).
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zeng-Feng Zhang, professor, Department of Microbiology, Guangxi Medical University,No.22 Shuangyong Road, Nanning, 530021, Guangxi Zhuang Autonomous Region, China. zfzhangphd@163.com
Received: February 28, 2023
Peer-review started: February 28, 2023
First decision: March 14, 2023
Revised: March 16, 2023
Accepted: April 13, 2023
Article in press: April 13, 2023
Published online: May 14, 2023
Core Tip

Core Tip: The failure rate of treating Helicobacter pylori (H. pylori) infectious diseases is increasing, leading to an urgent need to study and develop anti-H. pylori drugs. Banxia Xiexin decoction (BXXX) has a good effect on Hp infection and Hp-infection-related diseases. However, its pharmacological mechanism remains unclear, and whether it has an effect on drug-resistant H. pylori infection has not been confirmed by animal experiments. Our study confirms that BXXX decoction (BXXXT) has good therapeutic effects on drug-resistant H. pylori infection through in vivo and in vitro experiments in mice, then the composition of BXXXT and effective components, the immunomodulatory effect, the main target were verified. We preliminarily explain why BXXXT has a good effects.