Review
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 28, 2023; 29(12): 1795-1810
Published online Mar 28, 2023. doi: 10.3748/wjg.v29.i12.1795
Role of autoantibodies in the clinical management of primary biliary cholangitis
Eirini I Rigopoulou, Dimitrios P Bogdanos
Eirini I Rigopoulou, Department of Medicine and Research Laboratory of Internal Medicine, National Expertise Center of Greece in Autoimmune Liver Diseases, General University Hospital of Larissa, Larissa 41110, Greece
Eirini I Rigopoulou, European Reference Network on Hepatological Diseases (ERN RARE-LIVER), General University Hospital of Larissa, Larissa 41110, Greece
Dimitrios P Bogdanos, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa 41110, Greece
Author contributions: Rigopoulou EI had the original idea, wrote and revised the manuscript; Bogdanos DP wrote and revised the manuscript.
Conflict-of-interest statement: Eirini I Rigopoulou has nothing to declare; Dimitrios P Bogdanos has received lecture Honoria from Enorasis Hellas, Genesis Pharma, Novartis, Euroimmun, Menarini Hellas, Boehringer Ingelheim, Fresenius Kabi; Dimitrios P Bogdnaos has received grants to support the research and educational activities of his Department from Elpen, Boehringer Ingelheim, Demo and Menarini Hellas; Dimitrios P Bogdanos has received travel bursaries to attend scientific meetings and congresses from Werfen, Hospital Line, Pfizer, Elpen, Enorasis Hellas, Novartis and IFT Hellas.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Eirini I Rigopoulou, MD, PhD, Professor, Department of Medicine and Research Laboratory of Internal Medicine, National Expertise Center of Greece in Autoimmune Liver Diseases, General University Hospital of Larissa, Mezourlo, Larissa 41110, Greece. eirigopoulou@med.uth.gr
Received: December 5, 2022
Peer-review started: December 5, 2022
First decision: December 19, 2022
Revised: January 4, 2023
Accepted: March 14, 2023
Article in press: March 14, 2023
Published online: March 28, 2023
Core Tip

Core Tip: The diagnosis of primary biliary cholangitis (PBC) relies on the detection of disease-specific autoantibodies, including anti-mitochondrial antibodies and disease-specific antinuclear antibodies targeting sp100 and gp210. In this review, we summarize existing data on detection of PBC-related autoantibodies and their clinical significance. Moreover, we provide insight on novel autoantibodies and their possible prognostic role in PBC patients.