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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 21, 2022; 28(43): 6157-6167
Published online Nov 21, 2022. doi: 10.3748/wjg.v28.i43.6157
Published online Nov 21, 2022. doi: 10.3748/wjg.v28.i43.6157
Upper gastrointestinal endoscopic findings in celiac disease at diagnosis: A multicenter international retrospective study
Juan Pablo Stefanolo, María Luján Espinet, Edgardo Gustavo Smecuol, María Laura Moreno, Sonia Isabel Niveloni, Julio César Bai, Small Bowel Section, Dr. C. Bonorino Udaondo Gastroenterology Hospital, Buenos Aires 1264, Argentina
Fabiana Zingone, Ilaria Marsilio, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padova 35124, Italy
Fabiana Zingone, Gastroenterology Unit, Azienda Ospedale Università, Padova 35128, Italy
Carolina Gizzi, Carolina Ciacci, Department of Medicine, Surgery, Dentistry, Scuola Medica Salernitana, University of Salerno, Salerno 84081, Italy
Mark Khaouli, María I Pinto-Sánchez, Elena F Verdú, Department of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton L8S 4K1, Canada
Julio César Bai, Research Institutes, Universidad del Salvador, Buenos Aires 1020, Argentina
Author contributions: Stefanolo JP, Ciacci C, Zingone F, Gizzi C, Marsilio I, Espinet ML, Pinto-Sánchez MI, and Niveloni SI contributed with data acquisition; Stefanolo JP performed the statistical analysis; Stefanolo JP, Pinto-Sánchez MI, Ciacci C, Zingone F, and Bai JC contributed to study design; Verdú EF, Smecuol EG, Moreno ML contributed to critical analysis; Bai JC, Verdú EF, Ciacci C, Pinto-Sánchez MI and Zingone F contributed to writing and critical review of the manuscript; All authors read and approved the final manuscript.
Institutional review board statement: The Ethics and Research Board of the Dr. C. Bonorino Udaondo Gastroenterology Hospital approved the study because of the prospective design and intervention in the Buenos Aires cohort. Ethics approval was obtained from the Hamilton Integrated Research Ethics Board (HiREB# 14460/5415). In Italy, Ethical Committee review was not required for retrospective studies while patient data remained anonymously coded.
Informed consent statement: Informed consent was not required by the Ethics and Research Committee of the Hospital de Gastroenterología Dr. C. Bonorino Udaondo (Buenos Aires, Argentina) given the retrospective nature of the study and because this study was categorized as minimal risk by the Committee.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at jbai@intramed.net . Consent was not obtained, but the presented data are anonymized and risk of identification is low.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Julio César Bai, MD, Academic Research, Emeritus Professor, Small Bowel Section, Dr. C. Bonorino Udaondo Gastroenterology Hospital, Av. Caseros 2061, Buenos Aires 1264, Argentina. jbai@intramed.net
Received: August 24, 2022
Peer-review started: August 24, 2022
First decision: September 8, 2022
Revised: September 22, 2022
Accepted: November 7, 2022
Article in press: November 7, 2022
Published online: November 21, 2022
Peer-review started: August 24, 2022
First decision: September 8, 2022
Revised: September 22, 2022
Accepted: November 7, 2022
Article in press: November 7, 2022
Published online: November 21, 2022
Core Tip
Core Tip: We offer novel data on the prevalence of non-celiac endoscopic findings at the time of endoscopy performed to confirm celiac disease (CeD) diagnosis. Based on the very high performance of specific serology tests, the diagnosis of CeD without duodenal biopsy has been proposed in recent years. However, some guidelines do not recommend avoiding endoscopy because relevant comorbid diagnosis can be missed. Our results found that comorbid upper gastrointestinal endoscopic pathology is uncommon in patients with positive CeD serology at the time of diagnostic endoscopy suggesting that a non-biopsy strategy is unlikely to clinically miss significant concomitant endoscopic findings unrelated to CeD.