Basic Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 14, 2022; 28(26): 3177-3200
Published online Jul 14, 2022. doi: 10.3748/wjg.v28.i26.3177
Involvement of Met receptor pathway in aggressive behavior of colorectal cancer cells induced by parathyroid hormone-related peptide
María Belén Novoa Díaz, Pedro Carriere, Graciela Gigola, Ariel Osvaldo Zwenger, Natalia Calvo, Claudia Gentili
María Belén Novoa Díaz, Pedro Carriere, Graciela Gigola, Natalia Calvo, Claudia Gentili, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur (UNS)- INBIOSUR (CONICET-UNS), Bahía Blanca 8000, Buenos Aires, Argentina
Ariel Osvaldo Zwenger, Centro de Estudios Clínicos SAGA, CEC SAGA, Santiago de Chile 8320000, Chile
Author contributions: Novoa Díaz MB and Carriere P contributed to conceptualization, methodology, investigation, formal analysis, visualization, and manuscript drafting, review, and editing; Gigola G and Zwenger AO contributed to conceptualization, methodology, and investigation; Calvo N contributed to conceptualization, methodology, investigation, formal analysis, visualization, supervision, and manuscript drafting, review, and editing; Gentili C contributed to conceptualization, methodology, resources, investigation, formal analysis, visualization, supervision, manuscript drafting, review, and editing, project administration, and funding acquisition.
Supported by the Agencia Nacional de Promoción Científica y Tecnológica, No. PICT-2013-1441; Consejo Nacional de Investigaciones Científicas y Técnicas, No. PIP11220150100350; Instituto Nacional del Cáncer Asistencia Financiera II, RESOL 493/14, No. 2002-4395-14-1; Instituto Nacional del Cáncer Asistencia Financiera III-2016-2017, RESOL-2016-1006-E-APN-MS, No. 2002-3862-16-1 CANCER; Universidad Nacional del Sur, No. PGI: 24/B230 and No. PGI: 24/B303; and Fundación Alberto J. Roemmers of Argentina.
Institutional review board statement: The study was reviewed and approved by the committee of experts on the subject conformed by members of the Department of Biology, Biochemistry and Pharmacy of the National University of the South.
Institutional animal care and use committee statement: All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. All experiments with animals were approved by a local animal committee for ethics (CICUAE-UNS, institutional endorsement updated to 2021), and were carried out in accordance with the National Institutes of Health guide for the care and use of Laboratory animals (NIH 1996).
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Claudia Gentili, PhD, Professor, Research Scientist, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur (UNS)- INBIOSUR (CONICET-UNS), 670 San Juan, Bahía Blanca 8000, Buenos Aires, Argentina. cgentili@criba.edu.ar
Received: January 13, 2022
Peer-review started: January 13, 2022
First decision: March 8, 2022
Revised: March 21, 2022
Accepted: May 27, 2022
Article in press: May 27, 2022
Published online: July 14, 2022
Core Tip

Core Tip: Colorectal cancer (CRC) is one of the leading causes of cancer death, and chemoresistance is common in the treatment of CRC patients. Parathyroid hormone-related peptide (PTHrP) and the receptor tyrosine kinase Met are involved in the aggressive behavior of CRC cells. However, to date it is unknown whether PTHrP and Met are related to promoting events associated with the progression and chemoresistance of CRC. Herein we showed, for the first time, a PTHrP/Met axis that could have a positive impact on the knowledge of CRC biology and on the development of new targeted therapies.