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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 28, 2020; 26(44): 7022-7035
Published online Nov 28, 2020. doi: 10.3748/wjg.v26.i44.7022
Published online Nov 28, 2020. doi: 10.3748/wjg.v26.i44.7022
Prognostic value of changes in serum carcinoembryonic antigen levels for preoperative chemoradiotherapy response in locally advanced rectal cancer
Chinock Cheong, Jun Sang Shin, Kwang Wook Suh, Department of Surgery, Ajou University School of Medicine, Suwon 16499, Gyeonggi-do, South Korea
Author contributions: Cheong C conceived and designed the study, collected the data, and drafted the manuscript; Shin JS conducted and reviewed the research; Suh KW reviewed the draft.
Institutional review board statement: This study was approved by the Institutional Review Boards of the Ajou University School of Medicine (MED-MDB-18-329).
Conflict-of-interest statement: There are no conflicts of interest to declare.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Kwang Wook Suh, MD, PhD, Professor, Department of Surgery, Ajou University School of Medicine, 164 World Cup-ro, Yeongtong-gu, Suwon 16499, Gyeonggi-do, South Korea. suhkw@ajou.ac.kr
Received: August 6, 2020
Peer-review started: August 6, 2020
First decision: October 18, 2020
Revised: October 31, 2020
Accepted: November 13, 2020
Article in press: November 13, 2020
Published online: November 28, 2020
Peer-review started: August 6, 2020
First decision: October 18, 2020
Revised: October 31, 2020
Accepted: November 13, 2020
Article in press: November 13, 2020
Published online: November 28, 2020
Core Tip
Core Tip: The response of preoperative chemoradiotherapy (CRT) for rectal cancer varies from pathologic complete response to disease progression. Pre- and post-CRT levels of carcinoembryonic antigen can indicate treatment response to CRT in patients with locally advanced rectal cancer. Carcinoembryonic antigen can be used as a prognostic marker to facilitate treatment individualization in rectal cancer.