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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 14, 2020; 26(42): 6638-6657
Published online Nov 14, 2020. doi: 10.3748/wjg.v26.i42.6638
Published online Nov 14, 2020. doi: 10.3748/wjg.v26.i42.6638
Nomograms and risk score models for predicting survival in rectal cancer patients with neoadjuvant therapy
Fang-Ze Wei, Shi-Wen Mei, Jia-Nan Chen, Zhi-Jie Wang, Hai-Yu Shen, Juan Li, Fu-Qiang Zhao, Zheng Liu, Qian Liu, Department of Colorectal Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union College, Beijing 100021, China
Author contributions: Wei FZ and Chen JN designed the research; Mei SW, Wei FZ, Shen HY, Li J and Zhao FQ collected the data; Liu Z and Wei FZ analyzed the data; Wei FZ drafted the manuscript; Liu Q revised the manuscript.
Supported by The National Key Research and Development Plan "Research on Prevention and Control of Major Chronic Noncommunicable Diseases" , No. 2019YFC1315705 ; and the Medicine and Health Technology Innovation Project of the Chinese Academy of Medical Sciences , No. 2017-12M-1-006 .
Institutional review board statement: Our investigation received approval from the ethics committee of the National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College.
Informed consent statement: All patients signed informed consent forms.
Conflict-of-interest statement: The authors declare that they have no potential conflicts of interest.
Data sharing statement: No additional data are available.
STROBE statement: The authors have carefully read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Qian Liu, MD, Chief Doctor, Professor, Surgeon, Department of Colorectal Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. fcwpumch@163.com
Received: August 18, 2020
Peer-review started: August 18, 2020
First decision: September 12, 2020
Revised: September 15, 2020
Accepted: September 25, 2020
Article in press: September 25, 2020
Published online: November 14, 2020
Peer-review started: August 18, 2020
First decision: September 12, 2020
Revised: September 15, 2020
Accepted: September 25, 2020
Article in press: September 25, 2020
Published online: November 14, 2020
Core Tip
Core Tip: The manuscript focuses on the risk factors after administration of neoadjuvant therapy for locally advanced rectal cancer. We utilized the least absolute shrinkage and selection operator and Cox regression to identify risk factors for overall survival and disease-free survival and explore their prognostic value. Based on the factors, we built two nomograms and two risk factor score prediction models to predict survival time. The nomograms were validated by calibration and the concordance index, and the prediction model was validated with receiver operating characteristic curves. The risk factors included in the model and nomograms are associated with survival and recurrence and can aid physicians to improve patient survival.