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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 21, 2020; 26(11): 1142-1155
Published online Mar 21, 2020. doi: 10.3748/wjg.v26.i11.1142
Published online Mar 21, 2020. doi: 10.3748/wjg.v26.i11.1142
Effect of prolonged omeprazole administration on segmental intestinal Mg2+ absorption in male Sprague-Dawley rats
Nasisorn Suksridechacin, Punnisa Kulwong, Narongrit Thongon, Division of Physiology, Department of Biomedical Sciences, Faculty of Allied Health Sciences, Burapha University, Chonburi 20131, Thailand
Siriporn Chamniansawat, Division of Anatomy, Department of Biomedical Sciences, Faculty of Allied Health Sciences, Burapha University, Chonburi 20131, Thailand
Author contributions: Suksridechacin N performed experiments, analyzed the results, and edited the manuscript; Kulwong P performed experiments; Chamniansawat S performed experiments, analyzed the results, and wrote and edited the manuscript; Thongon N designed and performed experiments, analyzed and interpreted the results, and wrote and edited the manuscript.
Supported by Burapha University through National Research Council of Thailand , No. 15/2562 .
Institutional review board statement: This study was reviewed and approved by Institutional Review Committee ( ID# 23/2559).
Institutional animal care and use committee statement: This study was approved by the Ethics Committee on Animal Experiment of Burapha University, Thailand.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: The data could be downloaded from the public databases, and no additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Narongrit Thongon, PhD, Associate Professor, Division of Physiology, Department of Biomedical Sciences, Faculty of Allied Health Sciences, Burapha University, No. 169 Long-Hard Bangsaen Road, Saensook, Muang, Chonburi 20131, Thailand. narongritt@buu.ac.th
Received: November 18, 2019
Peer-review started: November 18, 2019
First decision: January 19, 2020
Revised: February 6, 2020
Accepted: March 5, 2020
Article in press: March 5, 2020
Published online: March 21, 2020
Peer-review started: November 18, 2019
First decision: January 19, 2020
Revised: February 6, 2020
Accepted: March 5, 2020
Article in press: March 5, 2020
Published online: March 21, 2020
Core Tip
Core tip: Proton pump inhibitors (PPIs) induced hypomagnesemia (PPIH) has attracted attention in the past decade. Previous studies proposed that PPIH is a consequence of intestinal Mg2+ malabsorption. However, the effect of prolonged PPI administration on duodenal, jejunal, ileal, and colonic Mg2+ absorption is largely unknown. In this study, the rats received 20 mg/ kg∙d subcutaneous omeprazole injection for 12 and 24 wk, which is comparable to 5 and 10 human years, respectively. Omeprazole injection induced hypomagnesemia with reduced urinary Mg2+ excretion. The rates of total, paracellular, and transcellular Mg2+ absorption reduced in the duodenum, jejunum, ilium, and colon were discovered in PPIH rats.