Basic Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 7, 2020; 26(1): 21-34
Published online Jan 7, 2020. doi: 10.3748/wjg.v26.i1.21
Feedback regulation between phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 and transforming growth factor β1 and prognostic value in gastric cancer
Qi Shao, Zhi-Ming Chen
Qi Shao, Zhi-Ming Chen, Department of Chemotherapy/Radiotherapy, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
Author contributions: Shao Q conducted the experiments and data analysis and drafted the manuscript; Chen ZM designed the project and revised the manuscript.
Institutional review board statement: This study was approved by the Ethics Committee of Affiliated Hospital of Nantong University.
Institutional animal care and use committee statement: This study does not include the animal experiments, so the institutional animal care use statement is not applicable to this manuscript.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: The bioinformatic data comes from the public databases, and no additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Zhi-Ming Chen, MSc, Doctor, Department of Radiotherapy, Affiliated Hospital of Nantong University, No. 10 Xisi Road, Nantong 226001, Jiangsu Province, China. czm614@163.com
Received: November 26, 2019
Peer-review started: November 26, 2019
First decision: December 12, 2019
Revised: December 15, 2019
Accepted: December 22, 2019
Article in press: December 22, 2019
Published online: January 7, 2020
Core Tip

Core tip: In this study, we fully identified the overexpression of phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 (PREX1) in gastric cancer and its positive correlation with the gastric cancer progression. High PREX1 expression predicts poor prognosis in the specific intestinal-type gastric cancer patients. PREX1 is closely involved with cell adhesion, and PREX1 has a positive feedback loop regulation with transforming growth factor β1 pathway to promote the metastasis of gastric cancer cells. PREX1 may be a novel target for the drug development of gastric cancer, and PREX1 acts as a predictor for prognosis of intestinal-specific gastric cancer.