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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 21, 2019; 25(27): 3634-3648
Published online Jul 21, 2019. doi: 10.3748/wjg.v25.i27.3634
Published online Jul 21, 2019. doi: 10.3748/wjg.v25.i27.3634
Bioartificial liver support systems for acute liver failure: A systematic review and meta-analysis of the clinical and preclinical literature
Yu-Ting He, Bing-Qi Zhang, Ji Bao, Laboratory of Pathology, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Ya-Na Qi, Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Jian-Bo Li, Department of Liver Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: He YT and Qi YN contributed equally to the work and are co-first authors. He YT and Bao J designed the research; He YT, Qi YN, and Zhang BQ contributed to literature selection and data extraction; He YT, Qi YN, Bao J, and Li JB contributed to analysis and interpretation of the data; He YT and Qi YN drafted the original manuscript; Bao J and Li JB revised the article; All authors have read the final article and approved the publication of the manuscript.
Conflict-of-interest statement: The authors have no conflict of interests to disclose.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Ji Bao, PhD, Associate Professor, Laboratory of Pathology, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University, No. 37, Guoxue Alley, Wuhou District, Chengdu 610041, Sichuan Province, China. baoji@scu.edu.cn
Telephone: +86-18980606618 Fax: +86-28-85164033
Received: March 20, 2019
Peer-review started: March 20, 2019
First decision: March 27, 2019
Revised: May 3, 2019
Accepted: May 31, 2019
Article in press: June 1, 2019
Published online: July 21, 2019
Peer-review started: March 20, 2019
First decision: March 27, 2019
Revised: May 3, 2019
Accepted: May 31, 2019
Article in press: June 1, 2019
Published online: July 21, 2019
Core Tip
Core tip: This systematic review and meta-analysis included a large number of studies about clinical trials and preclinical experiments of bioartificial liver (BAL) support systems for treating patients and large animal models with acute liver failure. We summarized the characteristics of studies, BAL, and outcomes in all the studies and compared the pooled effect by meta-analysis including only randomized controlled trial studies regarding mortality after BAL among humans and large animals, respectively.