Published online Feb 21, 2017. doi: 10.3748/wjg.v23.i7.1289
Peer-review started: October 9, 2016
First decision: November 9, 2016
Revised: December 8, 2016
Accepted: December 21, 2016
Article in press: December 21, 2016
Published online: February 21, 2017
Core tip: Functional lumen imaging probe (FLIP) uses impedance planimetry to calculate the distensibility of a hollow organ. In this systematic review, we aimed to assess FLIP reference values for gastroesophageal junction distensibility in healthy and diseased states. We found available normative data to vary widely. In achalasia, patients uniformly demonstrated low distensibility that improved after treatment, highlighting the role of FLIP in assessment of achalasia treatment efficacy. In gastroesophageal reflux disease, distensibility fell to the range of untreated achalasia following fundoplication, emphasizing the importance of pre-operative screening for esophageal body dysmotililty. Future studies using a standardized FLIP protocol and balloon size are needed.