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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 21, 2017; 23(47): 8376-8386
Published online Dec 21, 2017. doi: 10.3748/wjg.v23.i47.8376
Published online Dec 21, 2017. doi: 10.3748/wjg.v23.i47.8376
Nomogram based on tumor-associated neutrophil-to-lymphocyte ratio to predict survival of patients with gastric neuroendocrine neoplasms
Long-Long Cao, Jun Lu, Jian-Xian Lin, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Qi-Yue Chen, Mi Lin, Ru-Hong Tu, Chang-Ming Huang, Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian Province, China
Author contributions: Cao LL, Lu J, Lin JX and Huang CM conceived the study, analyzed the data, and drafted the manuscript; Zheng CH helped critically revise the manuscript for important intellectual content; Li P, Xie JW, Wang JB, Chen QY, Lin M and Tu RH helped collect the data and designed the study; All authors read and approved the final manuscript.
Supported by National Key Clinical Specialty Discipline Construction Program of China, No. [2012] 649.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Fujian Medical University Union Hospital.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest associated with the publication of this manuscript.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Chang-Ming Huang, Professor, Department of Gastric Surgery, Fujian Medical University Union Hospital, No. 29, Xinquan Road, Fuzhou 350001, Fujian Province, China. hcmlr2002@163.com
Telephone: +86-591-83363366 Fax: +86-591-83320319
Received: March 10, 2017
Peer-review started: March 11, 2017
First decision: May 9, 2017
Revised: June 3, 2017
Accepted: July 4, 2017
Article in press: July 4, 2017
Published online: December 21, 2017
Peer-review started: March 11, 2017
First decision: May 9, 2017
Revised: June 3, 2017
Accepted: July 4, 2017
Article in press: July 4, 2017
Published online: December 21, 2017
Core Tip
Core tip: The study aimed to assess the predictive value of the tumor-associated neutrophil-to-lymphocyte ratio in terms of the clinical outcomes of 142 patients diagnosed with gastric neuroendocrine neoplasms. We demonstrated that the tumor-associated neutrophil-to-lymphocyte ratio was significantly correlated with tumor recurrence, especially with liver and lymph node metastasis. Moreover, the tumor-associated neutrophil-to-lymphocyte ratio was found to be an independent predictor of recurrence-free survival and overall survival, and combining it with the Ki-67 index and lymph node ratio could improve prognosis prediction in patients with gastric neuroendocrine neoplasms, as could applying the traditional TNM staging system.