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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 28, 2017; 23(20): 3643-3654
Published online May 28, 2017. doi: 10.3748/wjg.v23.i20.3643
Published online May 28, 2017. doi: 10.3748/wjg.v23.i20.3643
Urinary metabolic insights into host-gut microbial interactions in healthy and IBD children
Francois-Pierre Martin, Seu Ping Guiraud, Martin Kussmann, Nestlé Institute of Health Sciences, 1015 Lausanne, Switzerland
Ming-Ming Su, Guo-Xiang Xie, Wei Jia, University of Hawaii Cancer Center, Honolulu, HI 96813, United States
Ming-Ming Su, Metabo-Profile Biotechnology (Shanghai) Co., Ltd., Shanghai 203230, China
Martin Kussmann, The Liggins Institute, The University of Auckland, 1023 Auckland, New Zealand
Jean-Philippe Godin, Nestlé Research Center, 1000 Lausanne 26, Switzerland
Andreas Nydegger, Division of Pediatric Gastroenterology, University of Lausanne, 1011 Lausanne, Switzerland
Author contributions: Martin FP, Godin JP, Jia W and Nydegger a conceived and designed the experiments; Su MM, Xie GX and Jia W performed the metabonomics experiments; Martin FP and Guiraud SP analyzed the data; all the authors wrote the paper.
Supported by Swiss National Science Foundation , No. 32003B_135466 .
Institutional review board statement: This clinical study was approved by the Ethical Committee of the University of Lausanne, Switzerland (protocol 69/10), and conducted in the Pediatric Gastroenterology outpatient clinic of the University Hospital of Lausanne, Switzerland.
Conflict-of-interest statement: FPM, SPG, JPG are employees of the Nestlé Group.
Data sharing statement: Data may be available upon request to Francois-Pierre Martin and Andreas Nydegger, subject in particular, to ethical and privacy considerations.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: François-Pierre Martin, PhD, Nestle Institute of Health Sciences, 1015 Lausanne, Switzerland. francois-pierre.martin@rd.nestle.com
Telephone: +0041-21-6326161
Received: February 7, 2017
Peer-review started: February 10, 2017
First decision: March 3, 2017
Revised: March 29, 2017
Accepted: May 4, 2017
Article in press: May 4, 2017
Published online: May 28, 2017
Peer-review started: February 10, 2017
First decision: March 3, 2017
Revised: March 29, 2017
Accepted: May 4, 2017
Article in press: May 4, 2017
Published online: May 28, 2017
Core Tip
Core tip: Despite the limited number of subjects, the longitudinal experimental design with a healthy reference group reveals insights into childhood metabolic status in relation to growth and disease. Metabolite profiling of urine samples collected non-invasively enables identification and monitoring of biochemical signatures linked to metabolic and nutritional requirements in pediatric populations with inflammatory bowel disease (IBD). In the present study, a distinct biochemical process related to glutathione, glycine and bile acid metabolism distinguished children with IBD from healthy matched controls.