Sarkar A, De R, Mukhopadhyay AK. Curcumin as a potential therapeutic candidate for Helicobacter pylori associated diseases. World J Gastroenterol 2016; 22(9): 2736-2748 [PMID: 26973412 DOI: 10.3748/wjg.v22.i9.2736]
Corresponding Author of This Article
Dr. Asish K Mukhopadhyay, Division of Bacteriology, National Institute of Cholera and Enteric Diseases, P 33, CIT Road, Scheme XM, Beliaghata, Kolkata 700010, India. asish_mukhopadhyay@yahoo.com
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Mar 7, 2016; 22(9): 2736-2748 Published online Mar 7, 2016. doi: 10.3748/wjg.v22.i9.2736
Curcumin as a potential therapeutic candidate for Helicobacter pylori associated diseases
Avijit Sarkar, Ronita De, Asish K Mukhopadhyay
Avijit Sarkar, Ronita De, Asish K Mukhopadhyay, Division of Bacteriology, National Institute of Cholera and Enteric Diseases, Kolkata 700010, India
Author contributions: Sarkar A, De R and Mukhpopadhyay AK wrote the manuscript; Sarkar A and Mukhopadhyay AK conceive the idea and design the review.
Conflict-of-interest statement: All authors declare no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Asish K Mukhopadhyay, Division of Bacteriology, National Institute of Cholera and Enteric Diseases, P 33, CIT Road, Scheme XM, Beliaghata, Kolkata 700010, India. asish_mukhopadhyay@yahoo.com
Fax: +91-33-23705066
Received: October 7, 2015 Peer-review started: October 8, 2015 First decision: December 11, 2015 Revised: January 1, 2016 Accepted: January 18, 2016 Article in press: January 18, 2016 Published online: March 7, 2016
Core Tip
Core tip: Curcumin, a yellow polyphenolic pigment, used as a food-coloring agent has wide range of beneficial properties (e.g., anti-inflammatory, anti-oxidant, anti-cancer, anti-proliferative, anti-fungal and anti-microbial). Several research groups have elucidated the role of curcumin in Helicobacter pylori (H. pylori) infection. This is the first review where we have discussed the role of curcumin as an anti-H. pylori agent along with its potential in other gastrointestinal diseases. Based on several in vitro, early cell culture, animal research and few pre-clinical trials, curcumin projected as a potential therapeutic candidate against H. pylori mediated gastric pathogenesis with a challenge to improve its low solubility and poor bioavailability.
