Copyright
©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 14, 2016; 22(46): 10198-10209
Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10198
Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10198
Nodular lymphoid hyperplasia: A marker of low-grade inflammation in irritable bowel syndrome?
Anna Chiara Piscaglia, Valentina Cesario, Giovanni Calò, Maria Loredana Stefanelli, Endoscopy and Gastroenterology Unit, Depatment of Internal Medicine, State Hospital, 47893 Borgo Maggiore, Republic of San Marino
Anna Chiara Piscaglia, Lucrezia Laterza, Viviana Gerardi, Rosario Landi, Loris Riccardo Lopetuso, Maria Loredana Stefanelli, Antonio Gasbarrini, School of Gastroenterology, Dept. of Internal Medicine and Gastroenterology, “Gemelli” Hospital, Catholic University, 00168 Rome, Italy
Giovanna Fabbretti, Massimo Brisigotti, Depatment of Pathology, “Infermi” Hospital, 47924 Rimini, Italy
Author contributions: Piscaglia AC provided study concept and design and performed all colonoscopies; Fabbretti G and Brisigotti M performed histological examination of all tissue samples; Laterza L, Cesario V, Gerardi V, Landi R, Lopetuso LR and Calò G contributed to the acquisition of data; Piscaglia AC and Laterza L performed analysis and interpretation of data; Piscaglia AC provided statistical analysis and drafted the manuscript; Laterza L, Stefanelli ML and Gasbarrini A provided critical revision of the manuscript for important intellectual content.
Institutional review board statement: The study was approved by the ethics committee of San Marino (Republic of San Marino).
Informed consent statement: Consent was not obtained, given the retrospective nature of the study, but the presented data are anonymized and risk of identification is low.
Conflict-of-interest statement: No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.
Data sharing statement: Dataset is available from the corresponding author at annachiarapiscaglia@hotmail.com.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Anna Chiara Piscaglia, MD, PhD, Endoscopy and Gastroenterology Unit, Depatment of Internal Medicine, State Hospital, Via Scialoja, 47893 Borgo Maggiore, Republic of San Marino. annachiarapiscaglia@hotmail.com
Telephone: +39-347-1015909
Received: July 24, 2016
Peer-review started: July 26, 2016
First decision: September 20, 2016
Revised: October 25, 2016
Accepted: November 14, 2016
Article in press: November 16, 2016
Published online: December 14, 2016
Peer-review started: July 26, 2016
First decision: September 20, 2016
Revised: October 25, 2016
Accepted: November 14, 2016
Article in press: November 16, 2016
Published online: December 14, 2016
Core Tip
Core tip: This study sheds light on colonic nodular lymphoid hyperplasia (NLH) in terms of prevalence, gender-distribution and association with known diseases. Our most relevant result is the identification of NLH as a putative marker of low-grade inflammation in a conspicuous subset of irritable bowel syndrome (IBS) cases. Further studies are required to understand the etiopathogenetic mechanisms underlying NLH in IBS, its association with metal contact allergies and its clinical implications.