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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 28, 2015; 21(28): 8569-8579
Published online Jul 28, 2015. doi: 10.3748/wjg.v21.i28.8569
Published online Jul 28, 2015. doi: 10.3748/wjg.v21.i28.8569
Association of hepatocyte-derived growth factor receptor/caudal type homeobox 2 co-expression with mucosal regeneration in active ulcerative colitis
Ferenc Sipos, Miklós Constantinovits, Györgyi Műzes, 2nd Department of Internal Medicine, Semmelweis University, 1088 Budapest, Hungary
Gábor Valcz, Zsolt Tulassay, Molecular Medicine Research Group, Hungarian Academy of Sciences, 1088 Budapest, Hungary
Author contributions: Sipos F, Constantinovits M, Valcz G, Tulassay Z and Műzes G substantially contributed to the conception and design of the study, acquisition, analysis and interpretation of data; all authors drafted the article and made critical revisions related to the intellectual content of the manuscript, and approved the final version of the article to be published.
Institutional review board statement: All routine colonic biopsy specimens and blood samples from the patients were taken after informed consent and ethical permission was obtained for participation in the study.
Conflict-of-interest statement: To the best of our knowledge, no conflict of interest exists.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ferens Sipos, MD, PhD, Assistant Professor of Gastroenterology, Immunology and Internal Medicine, 2nd Department of Internal Medicine, Semmelweis University, Szentkirályi street 46, 1088 Budapest, Hungary. dr.siposf@gmail.com
Telephone: +36-1-2660926 Fax: +36-1-2660816
Received: December 2, 2014
Peer-review started: December 3, 2014
First decision: April 13, 2015
Revised: April 25, 2015
Accepted: June 15, 2015
Article in press: June 16, 2015
Published online: July 28, 2015
Peer-review started: December 3, 2014
First decision: April 13, 2015
Revised: April 25, 2015
Accepted: June 15, 2015
Article in press: June 16, 2015
Published online: July 28, 2015
Core Tip
Core tip: HGFR+ cells in the circulation and lamina propria of active ulcerative colitis (UC) could also co-express caudal type homeobox 2 (CDX2), an epithelial stem cell marker, thus suggesting that HGFR+ cells have committed to the epithelial lineage. The presence of CD133/CDX2 and Musashi-1/CDX2 double positive cells in the subepithelial layer supports that mesenchymal-to-epithelial transition might be a crucial event in tissue regeneration of active UC.