Randomized Controlled Trial
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 14, 2015; 21(2): 661-666
Published online Jan 14, 2015. doi: 10.3748/wjg.v21.i2.661
Seven-day quintuple regimen as a rescue therapy for Helicobacter pylori eradication
Fariborz Mansour-Ghanaei, Farahnaz Joukar, Mohammad Reza Naghipour, Atena Forouhari, Seyed Mohammad Seyed Saadat
Fariborz Mansour-Ghanaei, Division of Gastroenterology and Hepatology, Gastrointestinal and Liver Diseases Research Center, Razi Hospital, Guilan University of Medical Sciences, Rasht 41448-95655, Iran
Farahnaz Joukar, Mohammad Reza Naghipour, Atena Forouhari, Seyed Mohammad Seyed Saadat, Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht 41448-95655, Iran
Author contributions: Mansour-Ghanaei F, Naghipour MR and Joukar F designed the study; Joukar F supervised the procedure and analyzed the data; Forouhari A collected data; Mansour-Ghanaei F, Joukar F and Seyed Saadat SM wrote the manuscript; all authors approved the final manuscript.
Supported by Gastrointestinal and Liver Diseases Research Center of Guilan University of Medical Sciences.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Fariborz Mansour-Ghanaei, MD, AGAF, Professor, Division of Gastroenterology and Hepatology, Gastrointestinal and Liver Diseases Research Center, Razi Hospital, Guilan University of Medical Sciences, Sardar Jangal Ave., Rasht 41448-95655, Iran. ghanaei@gums.ac.ir
Telephone: +98-131-5535116 Fax: +98-131-5534951
Received: June 2, 2014
Peer-review started: June 3, 2014
First decision: June 27, 2014
Revised: July 17, 2014
Accepted: September 18, 2014
Article in press: September 19, 2014
Published online: January 14, 2015
Core Tip

Core tip: Due to increasing antibiotic resistance, eradication of Helicobacter pylori has become more challenging. Antibiotic resistance exhibits a regional pattern and treatments typically involve 14-d medication periods, which are not always effective. This study compared two 7-d quintuple regimens and identified a regimen of bismuth subcitrate, omeprazole, tetracycline, metronidazole, and ofloxacin as an effective alternative second-line rescue therapy with minimal side effects for Iranian patients who failed a course of first-line treatment.