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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 28, 2015; 21(16): 4954-4960
Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4954
Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4954
Characteristics of gastric cancer in peptic ulcer patients with Helicobacter pylori infection
Jae Jin Hwang, Dong Ho Lee, Ae-Ra Lee, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Nayoung Kim, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do 463-707, South Korea
Author contributions: Hwang JJ and Lee DH were responsible for the study conception and design, data analysis and interpretation, and manuscript drafting; Lee A, Yoon H, Shin CM, Park YS and Kim N critically revised the article for important intellectual content; all the authors reviewed and approved the final version to be published.
Ethics approval: The study was reviewed and approved by the Seoul National University Bundang Hospital Institutional Review Board.
Conflict-of-interest: All the authors declare no potential conflicting interests related to this paper.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dong Ho Lee, MD, Department of Internal Medicine, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam, Gyeonggi-do 463-707, South Korea. dhljohn@yahoo.co.kr
Telephone: + 82-31-7877006 Fax: + 82-31-7874051
Received: October 15, 2014
Peer-review started: October 15, 2014
First decision: November 14, 2014
Revised: November 26, 2014
Accepted: January 16, 2015
Article in press: January 16, 2015
Published online: April 28, 2015
Peer-review started: October 15, 2014
First decision: November 14, 2014
Revised: November 26, 2014
Accepted: January 16, 2015
Article in press: January 16, 2015
Published online: April 28, 2015
Core Tip
Core tip: This is the first study to investigate gastric cancer (GC) incidence in peptic ulcer patients with Helicobacter pylori (H. pylori) infection and to compare GC clinical characteristics between patients with gastric ulcer (GU) and duodenal ulcer (DU) disease. The GC incidence rate and relative risk in GU patients with H. pylori infection were higher than in DU patients. The H. pylori eradication rate was lower in GU than in DU patients, although the success rate of therapy was lower than the failure rate in both groups. Atrophy of surrounding mucosa, intestinal metaplasia and H. pylori eradication therapy were significantly associated with GC.