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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 21, 2015; 21(11): 3361-3366
Published online Mar 21, 2015. doi: 10.3748/wjg.v21.i11.3361
Published online Mar 21, 2015. doi: 10.3748/wjg.v21.i11.3361
New therapeutic option for irritable bowel syndrome: Serum-derived bovine immunoglobulin
Larry Good, Department of Gastroenterology, South Nassau Communities Hospital, Oceanside, NY 11572, United States
Roxanne Rosario, Department of Research, Good Pharmaceutical Development Company, LLC, Lynbrook, NY 11563, United States
Raymond Panas, Department of Medical Affairs, Entera Health, Inc., Cary, NC 27518, United States
Author contributions: Good L and Rosario R had full access to review and pull available data from the medical records; Good L and Panas R consolidated and analyzed the collected data; Good L, Rosario R, and Panas R contributed to the organization and writing of the manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Larry Good, MD, Department of Gastroenterology, South Nassau Communities Hospital, No. 444 Merrick Road, Lynbrook, NY 11572, United States. good1b@optonline.com
Telephone: +1-516-766-0300 Fax: +1-516-766-2444
Received: August 19, 2014
Peer-review started: August 20, 2014
First decision: September 27, 2014
Revised: October 17, 2014
Accepted: December 16, 2014
Article in press: December 16, 2014
Published online: March 21, 2015
Peer-review started: August 20, 2014
First decision: September 27, 2014
Revised: October 17, 2014
Accepted: December 16, 2014
Article in press: December 16, 2014
Published online: March 21, 2015
Core Tip
Core tip: Oral prescription medical foods are becoming part of the outpatient medical practice and are finding new uses as a therapeutic option for gastrointestinal disorders. This case series investigates the use of oral serum-derived bovine immunoglobulin/protein isolate (SBI) in the management of differing forms of irritable bowel syndrome (IBS). Because of the multifaceted mechanism of action, SBI provides a distinct protein source to normalize bowel function, gastrointestinal microbiota, and nutritionally enhance tight junction protein expression. As such, there may be potential use for patients with other forms of IBS besides IBS-D. Additional research is needed to explore this use.