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World J Gastroenterol. Mar 7, 2014; 20(9): 2136-2142
Published online Mar 7, 2014. doi: 10.3748/wjg.v20.i9.2136
Published online Mar 7, 2014. doi: 10.3748/wjg.v20.i9.2136
Role of mitochondria in alcoholic liver disease
Fatiha Nassir, Jamal A Ibdah, Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65212, United States
Author contributions: Nassir F reviewed the literature and wrote the manuscript and Ibdah JA provided overall intellectual input into the design, contributed to writing, and edited the final version of the manuscript.
Correspondence to: Jamal A Ibdah, MD, PhD, AGAF, Professor, Director, Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Missouri School of Medicine, One Hospital Drive, CE 405, Columbia, MO 65212, United States. ibdahj@health.missouri.edu
Telephone: +1-573-8827349 Fax: +1-573-8844595
Received: October 29, 2013
Revised: December 24, 2013
Accepted: January 14, 2014
Published online: March 7, 2014
Revised: December 24, 2013
Accepted: January 14, 2014
Published online: March 7, 2014
Core Tip
Core tip: Excessive chronic or binge alcohol consumption causes alcoholic liver disease (ALD) with a spectrum ranging from simple steatosis to steatohepatitis and cirrhosis. One of the characteristics of ALD is the alteration in mitochondrial structure and function. This review summarizes some of the recent findings of the molecular mechanisms involved in the modulation of mitochondrial function and their implication in the development of ALD.