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World J Gastroenterol. Feb 28, 2014; 20(8): 2079-2084
Published online Feb 28, 2014. doi: 10.3748/wjg.v20.i8.2079
Published online Feb 28, 2014. doi: 10.3748/wjg.v20.i8.2079
Platelet count/spleen diameter ratio to predict esophageal varices in Mexican patients with hepatic cirrhosis
Alejandro González-Ojeda, Michel Dassaejv Macías-Amezcua, Mariana Chávez-Tostado, Kenia Militzi Ramírez-Campos, Anaís del Rocío Ramírez-Arce, Clotilde Fuentes-Orozco, Research Unit in Clinical Epidemiology, Specialties Hospital of the Western Medical Center, Medical Unit of High Specialty, Mexican Institute of Social Security, Guadalajara, CP 44340, Jalisco, México
Gabino Cervantes-Guevara, Gastroenterology Department, Hospital Civil de Guadalajara “Fray Antonio Alcalde”, Guadalajara, CP 44280, Jalisco, México
Manuela Chávez-Sánchez, Carlos Dávalos-Cobián, Susana Ornelas-Cázares, Gastroenterology Department, Specialties Hospital of the Western Medical Center, Medical Unit of High Specialty, Mexican Institute of Social Security, Guadalajara, CP 44340, Jalisco, México
Author contributions: González-Ojeda A, Cervantes-Guevara G, Chávez-Sánchez M, Dávalos-Cobián C, Ornelas-Cázares S, Macías-Amezcua MD, Chávez-Tostado M, Ramírez-Campos KM, Ramírez-Arce AR, Fuentes-Orozco C participated in the protocol design, collection of clinical information, statistical analysis and were involved in editing the manuscript; González-Ojeda A, Cervantes-Guevara G, Chávez-Sánchez M, Dávalos-Cobián C, Ornelas-Cázares S, Fuentes-Orozco C were involved in the protocol design, identification and inclusion of candidates and performed the intervention.
Correspondence to: Clotilde Fuentes-Orozco, MD, PhD, Research Unit in Clinical Epidemiology, Specialties Hospital of the Western Medical Center, Medical Unit of High Specialty, Mexican Institute of Social Security, Avenida Belisario Dominguez 1000, Colonia Independencia, Guadalajara, CP 44340, Jalisco, Mexico. clotilde.fuentes@gmail.com
Telephone: +52-33-31230241 Fax: +52-33-36182760
Received: September 26, 2013
Revised: October 25, 2013
Accepted: November 3, 2013
Published online: February 28, 2014
Revised: October 25, 2013
Accepted: November 3, 2013
Published online: February 28, 2014
Core Tip
Core tip: Using noninvasive parameters for high-risk esophageal varices may reduce the need for endoscopies. The ratio of platelet count/diameter of the spleen (PC/SD ratio) is the principal noninvasive predictor of esophageal varices for stratifying patients with cirrhosis. These parameters are easy to obtain, reproducible and noninvasive. In our study, the cutoff point for PC/SD ratio was lower than that reported in previous literature (< 884.3 and < 909, respectively), with a sensitivity of 84% and specificity of 70%. The differences are probably influenced by racial characteristics. The PC/SD ratio should be considered to identifying patients with esophageal varices.