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World J Gastroenterol. Dec 21, 2014; 20(47): 17737-17745
Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17737
Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17737
Intestinal microbiota and type 2 diabetes: From mechanism insights to therapeutic perspective
Jun-Ling Han, Hui-Ling Lin, Department of Endocrinology and Metabolism, the 187th Hospital of PLA, Haikou 571159, Hainan Province, China
Author contributions: Han JL and Lin HL wrote the paper.
Correspondence to: Jun-Ling Han, MD, Department of Endocrinology and Metabolism, the 187th Hospital of PLA, No. 100, Longkun South Road, Haikou 571159, Hainan Province, China. hanihelen@126.com
Telephone: +86-898-65920012 Fax: +86-898-65920100
Received: June 1, 2014
Revised: September 26, 2014
Accepted: November 18, 2014
Published online: December 21, 2014
Revised: September 26, 2014
Accepted: November 18, 2014
Published online: December 21, 2014
Core Tip
Core tip: Type 2 diabetes (T2DM) is believed to be caused by a series of multiple risk factors such as genetic liability, age, overweight or obesity, and an unhealthy lifestyle. Recently, accumulated evidence has suggested that the intestinal microbiota plays an important role in the pathogenesis of T2DM as a potential novel contributor. This review focuses on the underlying role of intestinal microbiota in the pathogenesis of T2DM and the therapeutic potential of modulating gut microbiota in T2DM.