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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 21, 2014; 20(43): 16268-16274
Published online Nov 21, 2014. doi: 10.3748/wjg.v20.i43.16268
Published online Nov 21, 2014. doi: 10.3748/wjg.v20.i43.16268
Insulin-like growth factor receptor-1 overexpression is associated with poor response of rectal cancers to radiotherapy
Xiao-Yu Wu, Zhen-Feng Wu, Qin-Hong Cao, Che Chen, Zhi-Wei Chen, Zhe Xu, Wei-Su Li, Fu-Kun Liu, Xue-Quan Yao, Department of Surgical Oncology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China
Gang Li, Department of General Surgery, Jiangsu Cancer Hospital, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing 210009, Jiangsu Province, China
Author contributions: Wu XY and Wu ZF contributed equally to this work; Wu XY and Wu ZF designed research; Wu XY and Wu ZF performed research; Cao QH and Chen ZW contributed new reagents or analytic tools; Wu ZF analyzed data; Wu XY wrote the paper; all the authors contributed to this paper.
Supported by The National Natural Science Foundation of China, No. 81402523 to Wu XY and No. 81201797 to Li G
Correspondence to: Gang Li, MD, Department of General Surgery, Jiangsu Cancer Hospital, Affiliated Cancer Hospital of Nanjing Medical University, 42 Baiziting, Nanjing 210009, Jiangsu Province, China. searain@sohu.com
Telephone: +86-25-86600460 Fax: +86-25-86600460
Received: January 27, 2014
Revised: May 2, 2014
Accepted: July 16, 2014
Published online: November 21, 2014
Revised: May 2, 2014
Accepted: July 16, 2014
Published online: November 21, 2014
Core Tip
Core tip: This was the first report examining the relation between insulin-like growth factor receptor-1 (IGF-1R) expression and radiosensitivity in rectal cancer. Results showed that IGF-1R hyperexpression is significantly associated with poor response to radiotherapy. Compared with the pre-radiation biopsy specimens, the paired post-operative specimens showed a significantly increased IGF-1R expression in the residual cancer cells.