Original Article
Copyright ©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 28, 2014; 20(40): 14895-14903
Published online Oct 28, 2014. doi: 10.3748/wjg.v20.i40.14895
Effect of oridonin-mediated hallmark changes on inflammatory pathways in human pancreatic cancer (BxPC-3) cells
Ru-Yi Chen, Bin Xu, Su-Feng Chen, Si-Si Chen, Ting Zhang, Jun Ren, Jian Xu
Ru-Yi Chen, Su-Feng Chen, Si-Si Chen, Ting Zhang, Jun Ren, Jian Xu, The College of Life Science, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China
Bin Xu, Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, Zhejiang Province, China
Author contributions: Chen RY, Xu B, Chen SF, Chen SS, and Xu J were involved in creating the study, conducting the experiments, data analysis, manuscript preparation and revision; Zhang T and Ren J were involved in the data analysis and critical manuscript revision.
Supported by The Qianjiang Talent Project of Zhejiang Province, No. 2013R10072; and the Natural Science Foundation of Zhejiang Province, Nos. LY14H160037 and LY12H16007
Correspondence to: Jian Xu, PhD, Associate Professor, The College of Life Science, Zhejiang Chinese Medical University, Bin Wen Road, Bin Jiang District, Hangzhou 310053, Zhejiang Province, China. xujian832002@163.com
Telephone: +86-571-86633001 Fax: +86-571-86613600
Received: May 2, 2014
Revised: June 29, 2014
Accepted: July 16, 2014
Published online: October 28, 2014
Core Tip

Core tip: Pancreatic cancer is a common cancer of the digestive system and is a leading cause of morbidity and mortality worldwide. In this report, we demonstrate that oridonin is able to inhibit the growth of human pancreatic cancer (BxPC-3) cells and change the expression of cancer hallmark-related proteins. Inflammatory factors were decreased in BxPC-3 cells treated with oridonin, and oridonin also regulated nuclear transcription factor pathways. We propose that oridonin can reduce growth, metastasis, and angiogenesis in BxPC-3 cells by regulating the nuclear transcription factor-mediated expression of related inflammatory factors.