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World J Gastroenterol. Oct 28, 2014; 20(40): 14841-14854
Published online Oct 28, 2014. doi: 10.3748/wjg.v20.i40.14841
Published online Oct 28, 2014. doi: 10.3748/wjg.v20.i40.14841
Gut-liver axis improves with meloxicam treatment after cirrhotic liver resection
Astrit R Hamza, Pramod Kadaba Srinivasan, Mamdouh Afify, René H Tolba, Institute for Laboratory Animal Science and Experimental Surgery, University Hospital Rheinisch-Westfälische Technische Hochschule Aachen, 52074 Aachen, Germany
Astrit R Hamza, Avdyl Krasniqi, Department of Abdominal Surgery, University Clinical Center of Kosova, Prishtina 10000, Kosovo
Christian Bleilevens, Department of Anesthesiology, University Hospital Rheinisch-Westfälische Technische Hochschule Aachen, 52074 Aachen, Germany
Uwe Klinge, Department of Surgery, University Hospital Rheinisch-Westfälische Technische Hochschule Aachen, 52074 Aachen, Germany
Author contributions: Hamza AR designed the study, performed experiments, collected and analyzed data, and wrote the article; Krasniqi AS designed the study and wrote the article; Srinivasan PK collected and analyzed data; Afify M analyzed histologic data; Bleilevens C performed polymerase chain reaction experiments and analysis; Klinge U performed collagen quantification; Tolba RH designed the study, analyzed data, revised the article and approved final version for publication.
Correspondence to: René H Tolba, MD, PhD, Professor, Director, Institute for Laboratory Animal Science and Experimental Surgery, University Hospital Rheinisch-Westfälische Technische Hochschule Aachen, Pauwelsstraße 30, 52074 Aachen, Germany. rtolba@ukaachen.de
Telephone: +49-241-8080472 Fax: +49-241-8082462
Received: February 22, 2014
Revised: June 7, 2014
Accepted: June 25, 2014
Published online: October 28, 2014
Revised: June 7, 2014
Accepted: June 25, 2014
Published online: October 28, 2014
Core Tip
Core tip: Cyclooxygenase-2 (COX-2) inhibitors have been used in liver cirrhosis (LC), suppressing inflammation and liver fibrosis. However, the effects of COX-2 inhibition on the gut-liver axis after cirrhotic liver resection was not investigated previously. For the first time it can be concluded that one single dose of meloxicam administered 15 min prior to a 50% hepatectomy in LC, alleviates impairment of many functions of the gut-liver axis such as microcirculation, hepatocyte and enterocyte regeneration rate, and gastrointestinal transit, enabling better function and integrity of the remaining liver and the small bowel.