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World J Gastroenterol. Sep 28, 2014; 20(36): 12874-12882
Published online Sep 28, 2014. doi: 10.3748/wjg.v20.i36.12874
Published online Sep 28, 2014. doi: 10.3748/wjg.v20.i36.12874
Potential role of metabolomics in diagnosis and surveillance of gastric cancer
Angela W Chan, Richdeep S Gill, Daniel Schiller, Division of General Surgery, University of Alberta, Edmonton, Alberta T6G 2B7, Canada
Michael B Sawyer, Division of Medical Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta T6G 1Z2, Canada
Author contributions: Chan AW performed the literature search and wrote the original manuscript; All authors collectively revised the manuscript and prepared it for submission.
Correspondence to: Michael B Sawyer, Associate Professor of Oncology, Division of Medical Oncology, Cross Cancer Institute, University of Alberta, 11560 University Avenue, Edmonton, Alberta T6G 1Z2, Canada. michael.sawyer@albertahealthservices.ca
Telephone: +1-780-4328248 Fax: +1-780-4328888
Received: October 28, 2013
Revised: February 16, 2014
Accepted: April 8, 2014
Published online: September 28, 2014
Revised: February 16, 2014
Accepted: April 8, 2014
Published online: September 28, 2014
Core Tip
Core tip: There are differences in metabolomic profiles of gastric cancer patients and healthy controls, as well as between different stages of gastric cancer. The transition from normal to malignant consistently shows upregulation in lactate and downregulation of glucose consistent with the Warburg effect. This trend is perpetuated as cells advance from non-invasive to invasive. Key tricarboxylic acid (TCA) cycle intermediates and amino acids are elevated as a result of anaplerotic reactions. Perpetuation of the TCA cycle generates energy for essential cell functions. There is less consistency between lipid and nucleic acid metabolites.