Case Control Study
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World J Gastroenterol. Sep 21, 2014; 20(35): 12566-12573
Published online Sep 21, 2014. doi: 10.3748/wjg.v20.i35.12566
Serum immunoglobulin A concentration is a reliable biomarker for liver fibrosis in non-alcoholic fatty liver disease
Iradj Maleki, Mahmood Reza Aminafshari, Tarang Taghvaei, Vahid Hosseini, Alireza Rafiei, Zhila Torabizadeh, Maryam Barzin, Elahe Orang
Iradj Maleki, Mahmood Reza Aminafshari, Tarang Taghvaei, Vahid Hosseini, Elahe Orang, Inflammatory Diseases of Upper Gastrointestinal Tract Research Center, Mazandaran University of Medical Sciences, Sari 48166-33131, Iran
Alireza Rafiei, Department of Immunology, Mazandaran University of Medical Sciences, faculty of Medicine, Sari 48166-33131, Iran
Zhila Torabizadeh, Department of Pathology, Mazandaran University of Medical Sciences, Imam Khomeini Hospital, Sari 48166-33131, Iran
Maryam Barzin, Department of Radiology, Mazandaran University of Medical Sciences, Imam Khomeini Hospital, Sari 48166-33131, Iran
Author contributions: Maleki I was involved in the design of the study, patient selection, supervision, statistical analysis, writing the manuscript and its revision; Aminafshari MR was involved in the design of the study, patient selection and supervision; Taghvaei T was involved in the design of the study, patient selection and writing the manuscript; Hosseini V was involved in the design of the study and patient selection; Rafiei A was involved in the design of the study and performance of the laboratory examinations; Torabizadeh Z was mainly involved in the study design and performance of the laboratory examinations; Barzin M was involved in the study design, and the ultrasound and imaging studies of the patients; Orang E was involved in the preparation of the study proposal and the manuscript.
Supported by Mazandaran University of Medical Sciences
Correspondence to: Zhila Torabizadeh, MD, Assistant Professor of Pathology, Department of Pathology, Mazandaran University of Medical Sciences, Imam Khomeini Hospital, Amir Mazandarani Street, Sari 48166-33131, Iran. zhtorabi@yahoo.com
Telephone: +98-911-1513073 Fax: +98-151-3218086
Received: January 26, 2014
Revised: April 20, 2014
Accepted: June 20, 2014
Published online: September 21, 2014
Core Tip

Core tip: Nonalcoholic steatohepatitis (NASH) is a severe subtype of Nonalcoholic Fatty Liver Disease (NAFLD) that can progress to advanced liver disease and hepatocellular carcinoma. In this study, we investigated the diagnostic accuracy of serum Immunoglobulin A (IgA) as a biomarker for differentiating early stage NAFLD from NASH. We found that the extent of liver fibrosis correlated positively with IgA levels and these were higher in NASH cases than in non-NASH cases. Based on receiver operating characteristic analysis, the best predictive IgA cutoff value for detecting liver fibrosis was 360 mg/dL (61% sensitivity, 81% specificity).