Mao JD, Wu P, Huang JX, Wu J, Yang G. Role of ERK-MAPK signaling pathway in pentagastrin-regulated growth of large intestinal carcinoma. World J Gastroenterol 2014; 20(35): 12542-12550 [PMID: 25253956 DOI: 10.3748/wjg.v20.i35.12542]
Corresponding Author of This Article
Pei Wu, Professor, Department of General Surgery, the First Affiliated Yijishan Hospital of Wannan Medical College, 10 Weiliu Road, Wuhu 241001, Anhui Province, China. maojiading0205@sina.com
Research Domain of This Article
Oncology
Article-Type of This Article
Original Article
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World J Gastroenterol. Sep 21, 2014; 20(35): 12542-12550 Published online Sep 21, 2014. doi: 10.3748/wjg.v20.i35.12542
Role of ERK-MAPK signaling pathway in pentagastrin-regulated growth of large intestinal carcinoma
Jia-Ding Mao, Pei Wu, Jian-Xiong Huang, Jian Wu, Guang Yang
Jia-Ding Mao, Pei Wu, Jian-Xiong Huang, Jian Wu, Guang Yang, Department of General Surgery, the First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu 241001, Anhui Province, China
Author contributions: Mao JD, Wu P and Huang JX designed research and performed research; Huang JX contributed new reagents/analytic tools; Mao JD analyzed data and wrote the paper; Wu J and Yang G contributed equally to this work.
Supported by Natural Science Foundation of Anhui Province, No. 1408085MH148; Natural Science Fund of Education Bureau of Anhui Province, No. kj2010b242; Natural Science Fund of Wannan Medical College, No. wk2012zf02; and The key science and technology project of Wuhu City, No. health-2-4
Correspondence to: Pei Wu, Professor, Department of General Surgery, the First Affiliated Yijishan Hospital of Wannan Medical College, 10 Weiliu Road, Wuhu 241001, Anhui Province, China. maojiading0205@sina.com
Telephone: +86-553-5739107 Fax: +86-553-5738100
Received: October 10, 2013 Revised: March 28, 2014 Accepted: May 28, 2014 Published online: September 21, 2014
Core Tip
Core tip: We have demonstrated that large intestinal carcinoma is related to abnormal expression of gastrin. Gastrin promoted growth of large intestinal cancer cell via gastrin receptor, but the detailed molecular mechanism is not fully known. We elucidated the molecular mechanisms of gastrin-induced growth of large intestinal cancer in relation to the extracellular signal-regulated protein kinase-mitogen-activated protein kinase (ERK-MAPK) signaling pathway. We attempted to establish a new gastrin-ERK-MAPK pathway in gastrin-dependent large intestinal cancer; provide a new way to interfere with the signaling pathway of gastrin-induced growth of large intestinal cancer; and to offer a new target for gene therapy of large intestinal carcinoma.
