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World J Gastroenterol. Aug 21, 2014; 20(31): 10729-10739
Published online Aug 21, 2014. doi: 10.3748/wjg.v20.i31.10729
Published online Aug 21, 2014. doi: 10.3748/wjg.v20.i31.10729
Involvement of eicosanoids in the pathogenesis of pancreatic cancer: The roles of cyclooxygenase-2 and 5-lipoxygenase
Lawrence M Knab, David J Bentrem, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, United States
Paul J Grippo, David J Bentrem, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, United States
David J Bentrem, Jesse Brown VA Medical Center, Chicago, IL 60612, United States
Author contributions: Knab LM, Grippo PJ and Bentrem DJ developed topic selection; Knab LM wrote the paper; Grippo PJ and Bentrem DJ revised the paper.
Correspondence to: David J Bentrem, MD, Department of Surgery, Northwestern University Feinberg School of Medicine, Northwestern University, Suite 650, 676 N St. Clair, Chicago, IL 60611, United States. dbentrem@nmff.org
Telephone: +1-312-6954113 Fax: +1-312-6951462
Received: October 26, 2013
Revised: January 30, 2014
Accepted: April 8, 2014
Published online: August 21, 2014
Revised: January 30, 2014
Accepted: April 8, 2014
Published online: August 21, 2014
Core Tip
Core tip: This review article highlights the relationship between inflammation and pancreatic cancer, specifically focusing on the enzymes cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX). The role of inflammation and tumor progression is a burgeoning area of research. This review delves into the research that has been conducted investigating COX-2 and 5-LOX and their relationship to pancreatic cancer both in vivo and in vitro. We discuss a variety of investigations including basic science, epidemiological, and clinical as they relate to pancreatic inflammation and eicosanoids.