Sostres C, Gargallo CJ, Lanas A. Interaction between Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs and/or low-dose aspirin use: Old question new insights. World J Gastroenterol 2014; 20(28): 9439-9450 [PMID: 25071338 DOI: 10.3748/wjg.v20.i28.9439]
Corresponding Author of This Article
Angel Lanas, MD, DSc, Clinical Chief, Professor, Service Department of Digestive Diseases, University Hospital Lozano Blesa, c/Domingo Miral s/n, 50009 Zaragoza, Spain. alanas@unizar.es
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
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World J Gastroenterol. Jul 28, 2014; 20(28): 9439-9450 Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9439
Interaction between Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs and/or low-dose aspirin use: Old question new insights
Carlos Sostres, Carla Jerusalen Gargallo, Angel Lanas
Carlos Sostres, Carla Jerusalen Gargallo, Angel Lanas, Service Department of Digestive Diseases, University Hospital Lozano Blesa, 50009 Zaragoza, Spain
Carlos Sostres, Carla Jerusalen Gargallo, Angel Lanas, Digestive Diseases Department, Aragon Health Sciences Institute, 50009 Zaragoza, Spain
Angel Lanas, CIBERehd, 08036 Barcelona, Spain
Angel Lanas, University of Zaragoza (Zaragoza), 50009 Zaragoza, Spain
Author contributions: Sostres C, Gargallo CJ and Lanas A contributed equally to the design, redaction drafting and reviewing process of this paper.
Correspondence to: Angel Lanas, MD, DSc, Clinical Chief, Professor, Service Department of Digestive Diseases, University Hospital Lozano Blesa, c/Domingo Miral s/n, 50009 Zaragoza, Spain. alanas@unizar.es
Telephone: +34-97-6765786 Fax: +34-97-6765787
Received: October 25, 2013 Revised: January 15, 2014 Accepted: April 8, 2014 Published online: July 28, 2014
Core Tip
Core tip:Helicobacter pylori (H. pylori) infection, nonsteroidal anti-inflammatory drugs (NSAID) or low dose aspirin use independently increases the risk for the development of peptic ulcer disease. In clinical practice, the presence of H. pylori infection associated with low dose aspirin and/or NSAID use in the same patient is becoming more frequent and therefore the potential interaction between these factors and the consequences of it has important implications. In real clinical practice, we can find different clinical scenarios involving these three factors associated with the presence of different gastrointestinal and cardiovascular risk factors. These huge variety of possible combinations greatly hinder the decision making process of physicians.
