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World J Gastroenterol. Jul 28, 2014; 20(28): 9392-9404
Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9392
Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9392
Pathophysiological roles of Pim-3 kinase in pancreatic cancer development and progression
Ying-Yi Li, Cancer Research Institute, Fudan University Shanghai Cancer Center, Shanghai 200433, China
Ying-Yi Li, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200433, China
Ying-Yi Li, Division of Molecular Bioregulation, Cancer Microenvironment Research Program, Cancer Research Institute, Kanazawa University, Kanazawa 920-1192, Japan
Naofumi Mukaida, Division of Molecular Bioregulation, Cancer Microenvironment Research Program, Cancer Research Institute, Kanazawa University, Kanazawa 920-1192, Japan
Author contributions: Li YY contributed to manuscript writing and final revision of the article; Mukaida N contributed to overall design, manuscript writing, and final revision of the article.
Supported by The National Science Foundation of China (in part), No. 30973476 and No. 812727
Correspondence to: Naofumi Mukaida, MD, PhD, Professor, Division of Molecular Bioregulation, Cancer Microenvironment Research Program, Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. mukaida@staff.kanazawa-u.ac.jp
Telephone: +81-76-2646735 Fax: +81-76-2344520
Received: October 25, 2013
Revised: January 22, 2014
Accepted: March 8, 2014
Published online: July 28, 2014
Revised: January 22, 2014
Accepted: March 8, 2014
Published online: July 28, 2014
Core Tip
Core tip: The present review describes the current knowledge on the roles of Pim-3 in pancreatic cancer development and progression, and provides the possibility for Pim-3 as a therapeutic target in human pancreatic cancer.