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World J Gastroenterol. Jul 28, 2014; 20(28): 9330-9337
Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9330
Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9330
Non-alcoholic fatty liver disease and obesity: Biochemical, metabolic and clinical presentations
Sandra Milić, Davorka Lulić, Davor Štimac, Division of Gastroenterology, Department of Internal Medicine, University Hospital Rijeka, Rijeka 51000, Croatia
Author contributions: Milić S, Lulić D and Štimac D performed data acquisition and wrote the manuscript; Milić S revised the manuscript; Štimac D approved the final manuscript version.
Correspondence to: Sandra Milić, MD, PhD, Professor, Division of Gastroenterology, Department of Internal Medicine, University Hospital Rijeka, Krešimirova 42, Rijeka 51000, Croatia. smilic05@gmail.com
Telephone: +385-51-658122 Fax: +385-51-658826
Received: October 29, 2013
Revised: January 26, 2014
Accepted: March 19, 2014
Published online: July 28, 2014
Revised: January 26, 2014
Accepted: March 19, 2014
Published online: July 28, 2014
Core Tip
Core tip: This article reviews biochemical, metabolic and clinical relationships between non-alcoholic fatty liver disease and obesity. Visceral adipose tissue influences hepatic steatosis to a greater extent than the body mass index, despite evidence that liver fat may develop independent of skeletal muscle and adipose tissue insulin resistance. Obese individuals with non-alcoholic fatty liver disease usually present with symptoms of metabolic syndrome or its components.