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World J Gastroenterol. Jul 21, 2014; 20(27): 8837-8845
Published online Jul 21, 2014. doi: 10.3748/wjg.v20.i27.8837
Published online Jul 21, 2014. doi: 10.3748/wjg.v20.i27.8837
Irritable bowel syndrome and food interaction
Rosario Cuomo, Paolo Andreozzi, Francesco Paolo Zito, Valentina Passananti, Giovanni De Carlo, Giovanni Sarnelli, Department Of Clinical Medicine and Surgery, Federico II University Hospital, School of Medicine, 80131 Naples, Italy
Author contributions: Cuomo R and Sarnelli G ideated the project; Cuomo R wrote the first draft of the manuscript; Andreozzi P, Zito FP, De Carlo G and Passananti V critically reviewed the manuscript; all authors approved the final version of the manuscript.
Correspondence to: Rosario Cuomo, MD, Associate Professor of Gastroenterology, Department of Clinical Medicine and Surgery, Federico II University Hospital, School of Medicine, Via S. Pansini 5, Building 6, 80131 Naples, Italy. rcuomo@unina.it
Telephone: +39-81-7463892 Fax: +39-339-7221830
Received: February 11, 2014
Revised: April 3, 2014
Accepted: June 2, 2014
Published online: July 21, 2014
Revised: April 3, 2014
Accepted: June 2, 2014
Published online: July 21, 2014
Core Tip
Core tip: The most of irritable bowel syndrome patients reported food as a trigger of gastrointestinal symptoms and self-referred intolerance to certain food items. However, it is difficult identify which items are involved in symptoms triggering because food is a complex milieu of several chemicals, almost all potentially able to induce symptoms via several ways. It has been proposed three pathogenic mechanisms by which food items might induce symptoms: via immune activation (food hypersensitivity), via direct action of bioactive molecules (food chemicals) and via luminal distension.