Correlations between skin lesions induced by anti-tumor necrosis factor-&alpha; and selected cytokines in Crohn's disease patients

doi:10.3748/wjg.v20.i22.7019

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Jun 14, 2014 (publication date) through Apr 28, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 14, 2014; 20(22): 7019-7026
Published online Jun 14, 2014. doi: 10.3748/wjg.v20.i22.7019

Correlations between skin lesions induced by anti-tumor necrosis factor-α and selected cytokines in Crohn's disease patients

Marcin Włodarczyk, Aleksandra Sobolewska, Bartosz Wójcik, Karolina Loga, Jakub Fichna, Maria Wiśniewska-Jarosińska

Marcin Włodarczyk, Aleksandra Sobolewska, Bartosz Wójcik, Karolina Loga, Maria Wiśniewska-Jarosińska, Department of Gastroenterology, Medical University of Lodz, 90-647 Lodz, Poland

Jakub Fichna, Department of Biochemistry, Medical University of Lodz, 92-215 Lodz, Poland

Author contributions: Włodarczyk M, Sobolewska A, Wójcik B, Loga K, Wiśniewska-Jarosińska M and Fichna J designed the research; Włodarczyk M, Sobolewska A, Wójcik B, Loga K and Wiśniewska-Jarosińska M performed the research; Włodarczyk M, Sobolewska A contributed new analytic tools; Włodarczyk M, Sobolewska A analyzed the data; Włodarczyk M, Sobolewska A, Wiśniewska-Jarosińska M and Fichna J wrote the paper; Włodarczyk M and Sobolewska A contributed equally to this study.

Supported by The student’s grant from the Foundation for Medical University of Lodz

Correspondence to: Maria Wiśniewska-Jarosińska, PhD, Department of Gastroenterology, Medical University of Lodz, Haller Sq. 1, 90-647 Lodz, Poland. maria.wisniewska-jarosinska@umed.lodz.pl

Telephone: +48-42-6393049 Fax: +48-42-6393049

Received: November 13, 2013
Revised: January 25, 2014
Accepted: March 6, 2014
Published online: June 14, 2014

Core Tip

Core tip: The important and often underestimated problem of skin lesions associated with biological treatment in Crohn’s disease. The authors found the correlation between the appearance of skin lesions and concentrations of interleukin (IL)-17A, IL-23 and interferon-γ in Crohn’s disease patients. This is a new and innovative view on the phenomenon “treat and trigger” in clinical practice. Better understanding the pathway of these disorders can influence the effectiveness of the treatment of skin lesions induced by biological therapy.