Noonavath RN, Lakshmi CP, Dutta TK, Kate V. Helicobacter pylori eradication in patients with chronic immune thrombocytopenic purpura. World J Gastroenterol 2014; 20(22): 6918-6923 [PMID: 24944483 DOI: 10.3748/wjg.v20.i22.6918]
Corresponding Author of This Article
Vikram Kate, MS, FRCS (Eng.), FRCS (Ed.), FRCS (Glasg.), PhD (Surg. Gastro.), MAMS, FIMSA, MASCRS, FACS, FACG, Professor of General and Gastrointestinal Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India. drvikramkate@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Evidence-Based Medicine
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Ravinder Naik Noonavath, Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India
Chandrasekharan Padma Lakshmi, Department of Medical Gastroenterology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India
Tarun Kumar Dutta, Department of Clinical Hematology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India
Vikram Kate, Department of General and Gastrointestinal Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India
Author contributions: Noonavath RN collected data, compiled the manuscript, literature review; Lakshmi CP performed data interpretation, literature review; Dutta TK contributed to data analysis, data interpretation, literature review, and supervised manuscript preparation; Kate V contributed to data analysis, design and overall conceptualization of the manuscript.
Correspondence to: Vikram Kate, MS, FRCS (Eng.), FRCS (Ed.), FRCS (Glasg.), PhD (Surg. Gastro.), MAMS, FIMSA, MASCRS, FACS, FACG, Professor of General and Gastrointestinal Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India. drvikramkate@gmail.com
Telephone: +91-413-2203330 Fax: +91-413-2272066
Received: December 7, 2013 Revised: January 18, 2014 Accepted: March 8, 2014 Published online: June 14, 2014
Core Tip
Core tip: Immune thrombocytopenic purpura (ITP) is an autoimmune haematological disorder in which destruction of platelets is mediated by auto-antibodies in the reticuloendothelial system. Some studies have demonstrated improvement in the platelet count after Helicobacter pylori (H. pylori) eradication in cITP. The present study describes the effect of H. pylori eradication on the platelet count in patients with cITP. It was found that following H. pylori eradication there was a significant sustained rise in the platelet count at 6 wk, 3rd and 6th months following eradication. In patients where conventional therapy was administrated, although there was a significant rise in the platelet count at 6 wk and 3rd month, it was found that at 6th month the platelet count was similar to the baseline pre therapy level.
