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World J Gastroenterol. May 14, 2014; 20(18): 5511-5518
Published online May 14, 2014. doi: 10.3748/wjg.v20.i18.5511
Published online May 14, 2014. doi: 10.3748/wjg.v20.i18.5511
Proteomic identification of tumor biomarkers associated with primary gallbladder cancer
Hai-Lin Huang, Department of General Surgery, Hospital of China Armed Police Forces, Nanchang 330030, Jiangxi Province, China
Hou-Shan Yao, Yi Wang, Wei-Jun Wang, Zhi-Qian Hu, Kai-Zhou Jin, Department of General Surgery, Shanghai Chang Zheng Hospital, Second Military Medical University, Shanghai 200003, China
Author contributions: Huang HL and Yao HS contributed equally to this work; Huang HL, Yao HS and Hu ZQ designed the research; Huang HL, Yao HS, Jin KZ and Wang WJ performed the research; Huang HL and Yao HS provided new reagents/analytic tools; Huang HL analyzed the data; Huang HL, Yao HS, Wang Y and Hu ZQ wrote the paper.
Correspondence to: Zhi-Qian Hu, MD, Department of General Surgery, Shanghai Chang Zheng Hospital, Second Military Medical University, 415 Feng Yang Road, Shanghai 200003, China. hzqcyto@126.com
Telephone: +86-21-81885591 Fax: +86-21-81885591
Received: October 30, 2013
Revised: January 22, 2014
Accepted: February 17, 2014
Published online: May 14, 2014
Revised: January 22, 2014
Accepted: February 17, 2014
Published online: May 14, 2014
Core Tip
Core tip: A new comparative proteomic study using human primary gallbladder cancer (PGC), cholecystitis and normal gallbladder tissues to identify biomarkers of PGC was performed. Three new potential biomarkers of PGC were validated and may be informative in understanding the carcinogenic mechanisms and monitoring the treatment of PGC.