Original Article
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World J Gastroenterol. Apr 21, 2014; 20(15): 4316-4328
Published online Apr 21, 2014. doi: 10.3748/wjg.v20.i15.4316
Non-transmissible Sendai virus vector encoding c-myc suppressor FBP-interacting repressor for cancer therapy
Kazuyuki Matsushita, Hideaki Shimada, Yasuji Ueda, Makoto Inoue, Mamoru Hasegawa, Takeshi Tomonaga, Hisahiro Matsubara, Fumio Nomura
Kazuyuki Matsushita, Fumio Nomura, Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan
Hideaki Shimada, Department of Surgery, School of Medicine, Toho University, Tokyo 143-8541, Japan
Yasuji Ueda, Makoto Inoue, Mamoru Hasegawa, DNAVEC Corporation, 6 Ohkubo, Tsukuba City, Ibaraki 300-2611, Japan
Takeshi Tomonaga, Proteome Research Center, Proteome Research Project, National Institute of Biomedical Innovation, Osaka 567-0085, Japan
Hisahiro Matsubara, Department of Frontier Surgery, Chiba University, Graduate School of Medicine, Chiba 260-8670, Japan
Author contributions: Matsushita K designed the research; Matsushita K, Ueda Y and Inoue M performed the research; Shimada H, Tomonaga T, Hasegawa M, Matsubara H and Nomura F contributed new reagents/analytic tools and scientific discussions; Matsushita K analyzed the data and wrote the paper.
Supported by In part by the 21st Century COE (Center Of Excellence) Programs to Dr. Takenori Ochiai and by a Grant-in-Aid 18591453 to K.M from the Ministry of Education, Science, Sports and Culture of Japan
Correspondence to: Kazuyuki Matsushita, MD, PhD, Associate Professor, Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-Ku, Chiba 260-8670, Japan. kmatsu@faculty.chiba-u.jp
Telephone: +81-43-2227171 Fax: +81-43-2262169
Received: October 22, 2013
Revised: December 14, 2013
Accepted: January 19, 2014
Published online: April 21, 2014
Core Tip

Core tip: The authors performed in vivo experiments and included an animal model to examine the Sendai virus/dF/Far Up Stream Element-Binding Protein-Interacting Repressor for cancer gene therapy to minimize side effects for clinical use.