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World J Gastroenterol. Dec 14, 2013; 19(46): 8758-8763
Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8758
Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8758
Association between TNF-α and IL-1β genotypes vs Helicobacter pylori infection in Indonesia
Yang Zhao, Department of Cancer Center, Second Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China
Yang Zhao, Jing-Wen Wang, Tsutomu Tanaka, Akihiro Hosono, Shinkan Tokudome, Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Aichi, Japan
Jing-Wen Wang, Bell Research Center for Reproductive Health and Cancer, Medical Corporation Kishokai, Nagoya 458-0818, Aichi, Japan
Ryosuke Ando, Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Aichi, Japan
Shinkan Tokudome, Department of Nutritional Epidemiology, National Institute of Health and Nutrition, Tokyo 162-8636, Japan
Soeripto, FX Ediati Triningsih, Tegu Triono, Suwignyo Sumoharjo, EY Wenny Astuti Achwan, Department of Anatomic Pathology, Gadjah Mada University Faculty of Medicine, Daerah Istimewa Yogyakarta 55281, Indonesia
Stephanus Gunawan, Department of Biomedical Research Unit, General Hospital of West Nusa Tenggara Province, Mataram 83117, Lombok, Indonesia
Yu-Min Li, First Department of General Surgery, Second Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China
Yu-Min Li, Gansu Provincial Key Laboratory of Digestive System Tumors, Lanzhou 730030, Gansu Province, China
Author contributions: Zhao Y performed the majority of experiments and wrote the manuscript; Wang JW give a help in statistics of the study; Tanaka T implementation of the H. pylori detection to collected samples by Urea breath test; Hosono A and Ando R participated sample collection in the local of Indonesia; Tokudome S designed the study and provided funding for this work; Soeripto, Triningsih FXE, Triono T, Sumoharjo S, Achwan EYWA, Gunawan S provided the collection of all the human material to this work; Li YM give a help to wrote the manuscript.
Correspondence to: Yu-Min Li, PhD, Professor, First Department of General Surgery, Second Hospital of Lanzhou University, 82 Cuiyingmen, Lanzhou 730030, Gansu Province, China. liym@lzu.edu.cn
Telephone: +86-931-8942744 Fax: +86-931-8458109
Received: July 17, 2013
Revised: October 9, 2013
Accepted: October 19, 2013
Published online: December 14, 2013
Revised: October 9, 2013
Accepted: October 19, 2013
Published online: December 14, 2013
Core Tip
Core tip: We found single nucleotide polymorphism of tumor necrosis factor-α and allele of interleukin-1β having high frequency in the healthy Indonesian population, which may be associated with potential contact with Helicobacter pylori (H. pylori) infection. Throughout, H. pylori studies were conducted in patients, and treatment was based on quadruple antibiotics to eradicate H. pylori infection in clinical trials. However, the implications of the individual differences in recurrent infections and drug resistance of H. pylori and other issues must be addressed. Therefore, vaccine development for prevention of H. pylori will be a topical issue in the coming years.